Can you use Salesforce for all emails (looking to replace Outlook completely)?

[JenniferMJoy]

Is it possible to get rid of Outlook and use only Salesforce for emailing/scheduling/contacts? Is there an app or a plug-in that I would need to simulate an email interface?

We already have marketing automation and mass email tools, but I am interested in finding out if its possible to solely use Salesforce for any and all emailing.  Does Salesforce have this capability?

If not, what other routes exist outside of using Outlook or Entourage? I am looking for something in the 'cloud' so that all of our information isn't stored on desktops.